METHOD FOR PREDICTION OF DURATION OF PRESERVATION OF POSITIVE EFFECT OF PHARMACOLOGICAL ANTIARRHYTHMIC THERAPY IN PATIENTS WITH EXTRASYSTOLIA Russian patent published in 2021 - IPC A61B5/02 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiology, and can be used to predict the duration of the preservation of the positive effect of pharmacological antiarrhythmic therapy (AAT) in patients with extrasystole. The method consists in the fact that before and after the AAT, used for at least 7 days, an electrocardiographic (ECG) study is performed daily and the extrasystole index (EI) is determined by the formula

EI = А÷В,

where EI is the index of extrasystole, A is the linear deviation (LD) of the corrected pre-ectopic interval (PEIcorr.) in at least 20 extrasystoles, calculated for left ventricular extrasystole or right ventricular extrasystole or atrial extrasystole, B is the number of extrasystoles used for research extrasystoles per hour. Then the corrected ΔEI (ΔEIcorr.) is calculated by the formula

ΔEIcorr.n = [(EIn - EIinit.) ÷ΔEIinit.] ÷√N,

where ΔEIcorr.n (in units) is the change in EI after each successive intake of one drug in comparison with the initial data, EI - EI values ​​before using the drug (initial data), EIn – EI values ​​of taking the drug during a short course of its use, N - coefficient corresponding to the number of consecutive days of taking the drug. With the slope of the linear regression ΔEIcorr. ≤0.06 units /ΔEIcorr. predict the duration of a positive clinical effect for less than 6 months, from 0.07 to 0.11 units / ΔEIcorr. - from 6 months to 1 year, ≥0.12 units / ΔEIcorr. - more than 1 year.

EFFECT: use of the invention makes it possible to predict the duration of the preservation of the positive effect of pharmacological AAT in patients with extrasystole.

1 cl, 12 tbl, 5 ex