METHOD FOR DETECTING STRUCTURAL AND METABOLIC CHANGES OF SUBCHONDRAL BONE IN PATIENTS WITH 0 AND I STAGES OF PRIMARY OSTEOARTHROSIS Russian patent published in 2024 - IPC G01N33/68 G01N33/49 G01N33/52 G01N33/543 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to traumatology, orthopaedics, rheumatology and clinical laboratory diagnostics, and can be used to detect structural and metabolic changes of subchondral bone in patients with 0 and I stages of primary osteoarthrosis. Whole venous blood samples are taken. Blood serum is obtained and determined by enzyme immunoassay of concentrations of tumour necrosis factor alpha TNFα and interleukins IL1-beta and IL10. Level of C3, C4 complement components is determined by immunoturbidimetry. In whole venous blood samples by flow cytometry concentration of T-cells CD3+ and CD3+CD8+ are determined. Coefficient of structural and metabolic changes of the subchondral bone P. If P is less than 0.5, no structural and metabolic changes of the subchondral bone are detected. If P is equal to or more than 0.5, the presence of structural and metabolic changes of the subchondral bone is detected.

EFFECT: method provides higher accuracy of detecting structural and metabolic changes of subchondral bone in patients with 0 and I stages of primary osteoarthrosis by using a combination of markers of systemic inflammatory response and cellular immunity.

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