FIELD: medicine, infectious diseases in particular.
SUBSTANCE: invention relates to the field of medicine, in particular to infectious diseases, phthisiology and therapy. A method for determining the genetic predisposition to the development of multidrug-resistant tuberculosis Mycobacterium tuberculosis is proposed. In patients at risk, venous blood samples are collected, genomic DNA is isolated, and an allele-specific polymerase chain reaction is performed to genotype the arylamine acetyltransferase 2 NAT2 gene at polymorphic loci rs1208, rs1799930, and rs1799929. Carriers of the combination of genotypes NAT2Lys268Lys А803А × NAT2Arg197Arg G590G × NAT2Leu161Leu С481С are predicted to develop multidrug-resistant tuberculosis Mycobacterium tuberculosis with a 10.775-fold risk. EFFECT: invention makes it possible to predict the development of multidrug-resistant tuberculosis Mycobacterium tuberculosis in HIV patients and to adjust the therapeutic tactics of managing patients at the stage of prescribing medicines.
2 cl, 2 tbl, 3 ex
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| METHOD FOR PREDICTING THE SURVIVAL PERIOD OF PATIENTS WITH THE CLINICAL COURSE OF HIV AND TUBERCULOSIS COINFECTION, ACCOMPANIED BY MULTIDRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS | 2021 |
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| METHOD FOR PREDICTION OF PULMONARY TUBERCULOSIS WITH MULTIPLE DRUG RESISTANCE | 2012 |
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| 5-METHYL-7-(3-NITRO-[1,2,4]TRIAZOL-1-YL)-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE, HAVING ANTI-TUBERCULOSIS ACTIVITY AGAINST THE AGENT WITH MULTIPLE DRUG RESISTANCE, AND A METHOD FOR PRODUCTION THEREOF | 2018 |
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| ANTI-TUBERCULOSIS AGENT | 2017 |
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RU2657423C1 |
