FIELD: production of a salt of branched oligohexamethylenguanidine (OHMG).
SUBSTANCE: present invention relates to variants of methods for producing a salt of branched oligohexamethylenguanidine (OHMG). The salt of branched oligohexamethylenguanidine has the general formula (I):
         (I),
 (I),
where R represents  or
 or  , and n1, n2, and n3 are equal to 1-3, z is 0.15-1.10 with an average molecular weight of Mn in the range from 850 to 1500 Da, selected from hydrochloride, hydrosuccinate, hydrocitrate, hydrosalicylate, hydrosulfosalicylate, having a purity sufficient for its use as a pharmaceutical substance.
, and n1, n2, and n3 are equal to 1-3, z is 0.15-1.10 with an average molecular weight of Mn in the range from 850 to 1500 Da, selected from hydrochloride, hydrosuccinate, hydrocitrate, hydrosalicylate, hydrosulfosalicylate, having a purity sufficient for its use as a pharmaceutical substance. 
EFFECT: production of branched oligohexamethylenguanidine salts with reproducible molecular characteristics and physico-chemical properties and a reduced content of ballast and toxic substances and a degree of purity sufficient for their use as a pharmaceutical substance.
10 cl, 6 tbl, 13 ex
| Title | Year | Author | Number | 
|---|---|---|---|
| METHOD OF PRODUCING BRANCHED OLIGOHEXAMETHYLENE GUANIDINE SALTS HAVING DEGREE OF PURITY SUFFICIENT FOR USE THEREOF AS PHARMACEUTICAL SUBSTANCE | 2019 | 
 | RU2729421C1 | 
| METHOD OF SYNTHESIS OF POLYHEXAMETHYLENE-GUANIDINE HYDROCHLORIDE | 2001 |  | RU2191606C1 | 
| GUANIDINE DERIVATIVE BASED BRANCHED OLIGOMERS AND DISINFECTANT CONTAINING SAID OLIGOMERS | 2010 | 
 | RU2443684C1 | 
| COMBINED DRUG PREPARATION IN FORM OF SOLUTION FOR PREPARING SPRAY FOR TREATING DISEASES OF ORAL CAVITY | 2018 | 
 | RU2687745C1 | 
| METHOD OF PRODUCING HIGHLY PURIFIED DISINFECTANT | 2012 | 
 | RU2500667C1 | 
| METHOD FOR PURIFYING POLYGUANIDINE DISINFECTING AGENT FROM PARENT MONOMERS | 2003 | 
 | RU2237682C1 | 
| DENTAL GEL WITH ANTIBACTERIAL EFFECT | 2023 | 
 | RU2817976C1 | 
| METHOD OF PRODUCING POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE | 2012 | 
 | RU2489452C1 | 
| METHOD OF PREPARING DISINFECTING AGENT | 1999 | 
 | RU2172748C2 | 
| OPHTHALMIC PREPARATION IN THE FORM OF EYE DROPS FOR PREVENTING AND TREATING INFECTIOUS CONJUNCTIVITIS CAUSED BY BACTERIA AND VIRUSES | 2019 | 
 | RU2699377C1 | 
Authors
Dates
2021-07-05—Published
2020-06-12—Filed