FIELD: biotechnology.
SUBSTANCE: group of inventions relates to the field of medicine and pharmaceutics. The first object is a liposomal composition containing liposomes for oral delivery of a peptide drug, protein, or antibody, and those liposomes contain tetraester lipids (TEL) and cell-penetrating peptides (CPP), wherein those CPP are attached to a compound that is part of the lipid bilayer of the liposome. The second and third objects represent the application of a liposomal composition for oral delivery of a peptide drug, protein, or antibody.
EFFECT: technical result is to protect the peptide drug, protein or antibody in passing through the stomach and improve absorption through the gastrointestinal barrier using the composition of the invention.
15 cl, 24 dwg, 2 tbl, 18 ex
| Title | Year | Author | Number |
|---|---|---|---|
| LIPOSOMAL COMPOSITIONS AND SOLID PERORAL MEDICINAL FORMS COMPRISING SUCH COMPOSITIONS | 2018 |
|
RU2751192C2 |
| LIPOSOMAL COMPOSITIONS USED FOR DRUG DELIVERY | 2015 |
|
RU2757110C2 |
| LIPOSOMAL COMPOSITIONS APPLICABLE FOR DRUG DELIVERY | 2005 |
|
RU2574926C2 |
| LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, PHARMACEUTICAL COMPOSITION AND METHOD FOR MULTIPLE SCLEROSIS TREATMENT | 2013 |
|
RU2639497C2 |
| MODIFIED PROTEINS, CONSTRUCTED TOXINS AND METHODS FOR PRODUCTION THEREOF | 2002 |
|
RU2305684C2 |
| PEPTIDE ANTIGEN OBTAINED FROM HEPATITIS b PROTEIN A (VARIANTS), PH-SENSITIVE LIPOSOME FOR INDUCTION OF CELLULAR IMMUNITY AGAINST HEPATITIS B VIRUS | 1998 |
|
RU2189989C2 |
| ANTITUMOR LIPOSOMAL PREPARATION WITH DIRECTED EFEFCT | 2005 |
|
RU2292898C1 |
| ANALOGUES OF LONG-ACTING PEPTIDES | 2012 |
|
RU2664859C2 |
| IMPROVED LIPOSOMES AND THEIR APPLICATION | 2008 |
|
RU2482837C2 |
| PHARMACEUTICAL COMPOSITION FOR TREPOSTINIL CONTROLLED RELEASE | 2019 |
|
RU2796305C2 |
