COMPOUNDS FOR TARGETED DELIVERY OF MEDICINE AND ENHANCED SIPHK ACTIVITY Russian patent published in 2017 - IPC C07C237/08 C07C323/41 C07C333/04 A61K9/127 A61K47/18 

FIELD: pharmacology.

SUBSTANCE: in formula , R₁ and R₂ are independently selected from the group consisting of C₁₂-C₁₈ alkyl, C₁₂-C₁₈ alkenyl and oleyl group; R₃ and R₄ are independently selected from the group consisting of C₁-C₆ alkyl and C₂-C₆ alkanol; X is selected from the group consisting of -CH₂- and -S-, or absent; Y is selected from -(CH₂)_n and -S(CH₂)_n , where n is 1 to 4; a=1-4; b=1-4; c=1-4 and Z is a counter ion. The invention also relates to a star-cell-specific drug carrier comprising a star-cell-specific amount of a retinoid molecule and a cationic lipid consisting of a compound of formula I.

EFFECT: improved delivery of therapeutic drugs and increased activity thereof.

31 cl, 16 dwg, 14 tbl, 43 ex