FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. A group of inventions is described, including an oligonucleotide containing a modified nucleic acid for the prevention, facilitation or treatment of blood cancer with the formation of a G-quadruplex structure, a composition for the prevention, amelioration or treatment of blood cancer, containing an effective amount of the above oligonucleotide, a composition for prevention, relief the course or treatment of blood cancer resistant to at least one of cytarabine, decitabine and azacitidine, as inhibitors of DNA synthetase or DNA methyltransferase, a composition for the prevention, amelioration or treatment of acute myeloid leukemia, having the effects of inducing apoptosis on bone marrow mononuclear cells obtained from patients with recurrent/difficult to treat acute myeloid leukemia, and a composition for alleviating the course or treatment of blood cancer, which has higher effects of inducing apoptosis in cancer cells than in normal cells.
EFFECT: invention expands the arsenal of tools for the prevention, relief or treatment of blood cancer.
7 cl, 8 dwg, 4 tbl, 9 ex
