IMMUNOSTIMULATING G,U-CONTAINING OLYGORIBONUCLEOTIDES Russian patent published in 2007 - IPC A61K31/7088 A61P37/04 

Abstract RU 2302865 C2

FIELD: biology.

SUBSTANCE: invention relates to compositions containing immunostimulating RNA olygomers and uses thereof. Claimed molecules of immunostimulating RNA having chain length of 5-40 nucleotides and including at least one guanine and at least one uracyl have immunostimulating properties and represent exclusive ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8).

EFFECT: composition and methods for stimulation of immune response activation.

120 cl, 23 ex, 20 dwg

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RU 2 302 865 C2

Authors

Lipford Grehjson B.

Bauer Shtefan

Vagner Khermann

Dates

2007-07-20Published

2003-04-04Filed