METHOD FOR ASSESSING THE RISK OF DEVELOPMENT OF SEVERE COVID-19 Russian patent published in 2021 - IPC A61B5/00 G01N33/569 C12Q1/6858 C12Q1/6874 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to molecular genetic diagnosis, and can be used to assess the risk of developing a severe form of COVID-19. Biological material is collected, genomic DNA is isolated, followed by genotyping of the HLA-A gene alleles, and the risk of developing a severe form of COVID-19 is predicted based on the results of genotyping. Based on the results of genotyping, the presence of the alleles HLA-A*01:01, HLA-A*02:01 and HLA-A*03:01 is determined. A high risk of developing a severe form of COVID-19 is predicted if homozygosity is detected for the HLA-A*01:01 allele, a low risk - when homozygosity is detected for the HLA-A*02:01 or HLA-A*03:01 alleles or heterozygosity with a pair of alleles HLA-A*02:01, HLA-A*03:01.

EFFECT: invention provides an opportunity to improve the accuracy of predictive assessments of the risk of developing a severe form of COVID-19 for persons of the Russian population aged 35 to 60 years by genotyping the alleles of the HLA-A gene and predicting the risk of developing a severe form of COVID-19 upon detection of the presence of certain alleles of the HLA-A.

2 cl, 4 dwg, 2 ex