METHOD FOR PREDICTING THE RISK OF DEVELOPING COVID-19 IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES Russian patent published in 2022 - IPC G01N33/50 C12Q1/6806 C12Q1/6827 C12Q1/686 C12Q1/6883 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncohematology, and can be used to predict the risk of an infection caused by SARS-CoV-2 with lung damage in patients with hematological malignancies. The polymorphism of the IL4 and IL10 genes in genomic DNA isolated from whole blood leukocytes is assessed. An analysis of the distribution of genotypes of the studied loci is carried out. In case of detection of combinations of genotypes of loci IL10-1082TT × IL4-590CC × IL10-819AG, IL10-1082TT × IL4-590TT × IL10-819AA, IL10-1082TT × IL4-590TT × IL10-819AG, IL10-59 × IL10-819AG, IL10-59 × IL10-819AG, IL10-1082TC × IL4-590ct × IL10-819AG, IL10-1082TC × IL4-590TT × IL10-819AA, IL10-1082ts × IL4-590TT × IL10 819AG, IL10-1082CC × IL4-590TT × IL10-819AA, IL10-1082CC × IL4-590TT × IL10-819AG a high risk of lung injury with COVID-19 is predicted.

EFFECT: method provides effective prediction of the risk of developing COVID-19 with lung damage in patients with hematological malignancies by analyzing the distribution of the genotypes of the IL4 and IL10 loci.

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