METHOD FOR OBTAINING CHITOSAN NANOPARTICLES WITH INCLUDED CIPROFLOXACIN Russian patent published in 2021 - IPC A61K9/51 B82B3/00 B82Y40/00 A61K31/496 

FIELD: chitosan nanoparticles production.

SUBSTANCE: invention relates to a method for producing chitosan nanoparticles with incorporated ciprofloxacin, in which a solution of ciprofloxacin (2 mg/ml) is added to a solution of chitosan in a 0.5% solution of acetic acid (4 mg/ml, pH 4.6), after which a solution of ciprofloxacin (2 mg/ml) is added dropwise into within 5 min add a solution containing 4 mg / ml sodium tripolyphosphate and 20 mg/ml octanoic acid, then the mixture is stirred for 1 h at (26±1)°С, nanoparticles are separated by centrifugation at 5000 rpm for 30 min.

EFFECT: developed a method for producing chitosan nanoparticles with incorporated ciprofloxacin, with a high efficiency of incorporating the active substance due to the introduction of octanoic acid into the composition.

1 cl, 1 ex