AGENT FOR TREATMENT OF EYE DISEASES AND METHOD OF ITS USE Russian patent published in 2018 - IPC A61K33/42 A61K31/722 A61K31/5377 A61K38/05 A61K47/00 A61K9/14 A61K9/08 A61K9/19 B82Y5/00 A61P27/02 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to ophthalmology and pharmaceutics, namely to medicines for ophthalmic use. Agent for treating ocular diseases comprises calcium-phosphate coated nanoparticles comprising the active substance and water. Calcium phosphate nanoparticles include an amorphous phase, which is amorphous calcium phosphate, and a crystalline structure that is brushite. Coating is made of chitosan. Nanoparticles have a hydrodynamic radius of 30 to 130 nm, surface charge +16±4 mV. pH of aqueous solution is 6.2–7.5. Agent may be in form of a freeze dried powder. Product has prolonged action. New agent is instillated into conjunctival cavity at effective concentration of 0.1–0.3 %.

EFFECT: technical result of proposed group of inventions is possibility of reducing the dose and frequency of using an ophthalmic agent with a reduction in local and systemic side effects.

7 cl, 1 dwg, 6 ex, 8 tbl