FIELD: medicine.
SUBSTANCE: invention relates to medicine. The essence of the invention lies in the fact that polymorphism of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) gene is determined in leukocytes of peripheral venous blood in women with widespread genital endometriosis and endometriosis-associated infertility, and upon detection of the carriage of the MTHFR 677T allele in homozygotic or embryos with an accuracy of 77%. Invention can be used to predict aneuploidy of embryos in the program of in vitro fertilization (IVF) in women with advanced genital endometriosis and endometriosis-associated infertility.
EFFECT: method does not affect the IVF procedure, is non-invasive for oocytes and embryos and allows women to be identified in the risk group for receiving aneuploid embryos from them, provides a personalized approach to the appointment of pre-implantation genetic testing, which contributes to an increase in the efficiency of the IVF procedure.
1 cl, 1 tbl, 3 ex
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