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2 766 750

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(51)

IPC

G01N33/58(2006-01-01)

C12Q1/6827(2018-01-01)

C12Q1/686(2018-01-01)

(21) (22)

Application

2021111133, 2021-04-19

(24)

Start date

2021-04-19

(22)

Actual filing date

2021-04-19

(45)

Published

2022-03-15

(72)

Inventor

Kudryavtseva Elena VladimirovnaKovalev Vladislav ViktorovichPotapov Nikolaj Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Vo Ugmu Minzdrava Rossii)

METHOD FOR PREDICTION OF NON-DEVELOPING PREGNANCY IN NORMAL EMBRYO KARYOTYPE Russian patent published in 2022 - IPC G01N33/58 C12Q1/6827 C12Q1/686

Abstract RU 2766750 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to obstetrics, and aims at prediction of non-developing pregnancy in normal embryo karyotype. Woman’s medical history is determined: a history of infertility, adenomyosis, thrombocyte count. Analysis of polymorphisms is performed PAI1-675 5G/4G, MTHFR C677T, MTRR A66G, NOS3 C-786T. Partner’s spermogram is examined. Prognostic index Z is calculated by formula Z=1.8X₁+1.8X₂+0.008X₃+0.3X₄+X₅+1.7X₆+1.2X₇-1.7X₈-2.79. If Z > 0, a high risk of a missed pregnancy is predicted in the presence of an embryo with a normal karyotype; if Z < 0, a low risk is predicted.

EFFECT: invention provides more effective prediction of non-developing pregnancy in normal embryo karyotype, as well as ease of implementation.

1 cl, 2 dwg, 2 tbl, 3 ex

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RU 2 766 750 C1

Authors

Kudryavtseva Elena Vladimirovna

Kovalev Vladislav Viktorovich

Potapov Nikolaj Nikolaevich

Dates

2022-03-15—Published

2021-04-19—Filed