FIELD: medicine.
SUBSTANCE: invention relates to the field of personalized medicine and concerns a method for determining genetic markers of polygenic risk of breast cancer (BC). A method for analyzing 30 genetic markers to assess the polygenic risk of developing a hormone-positive subtype of breast cancer is proposed: TGFBR2 (rs12493607), 18q11.2 (rs527616), 19p13 (rs2363956), 19p13 (rs8170), 22q12.2 (rs132390), 2q31.1 (rs2016394), 3p26.2 (rs6762644), 7q35 (rs720475), 8q24 (RS13281615), 9q31 (rs865686), ADAM29 (RS6828523), ANKRD16 (RS2380205), CCDC88C (RS941764), CCND1 (RS554219), CCND1 (RS75915166), CDYL2 (RS13329835), CHST9 (RS1436904), COX11 (RS6504950), DNAJC1 (rs7072776), LGR6 (rs6678914), MAP3K1 (rs889312), MDM4 (rs4245739), NRIP1 (rs2823093), PAX9 (rs2236007), RAD51L1 (rs2588809), RANBP1 (rs204247), SLC4A7 (rs4973768), TERT (rs10069690), TET2 (rs9790517), ZMIZ1 (rs704010). A set of oligonucleotide probes necessary for the identification of genetic markers of polygenic risk of developing a hormone-positive subtype of breast cancer is proposed.
EFFECT: invention provides for simultaneous determination of genotypes at selected loci using multiplex PCR and subsequent hybridization with an oligonucleotide biological microchip (biochip).
2 cl, 2 dwg, 2 tbl, 4 ex
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