FIELD: pharmaceuticals.
SUBSTANCE: invention refers to pharmacogenetics and personalized medicine. Disclosed is a method of analysing polymorphous markers in the SLCO1B1, APOE and ABCB1 genes to determine individual sensitivity to statins, comprising the following steps: amplification by multiplex single-step PCR, providing a biochip, hybridising the fluorescent labeled PCR product on the biochip and recording and interpreting the hybridisation results.
EFFECT: invention provides detecting the following polymorphous markers: SLCO1B1 (rs4149056, rs4149015), APOE (rs7412), ABCB1 (rs2032582).
1 cl, 2 dwg, 2 tbl, 4 ex
| Title |
Year |
Author |
Number |
| METHOD OF ANALYZING POLYMORPHIC MARKERS IN THE GENES VKORC1, CYP4F2, CYP2C9, CYP2C19, ABCB1, ITGB3 TO DETERMINE INDIVIDUAL SENSITIVITY TO ANTICOAGULANT DRUGS |
2018 |
- Ikonnikova Anna Yurevna
- Nasedkina Tatyana Vasilevna
- Zasedatelev Aleksandr Sergeevich
|
RU2689400C1 |
| METHOD OF DETERMINING POLYMORPHIC MARKERS IN CYP2C19 AND CYP2D6 GENES FOR DETERMINING INDIVIDUAL SENSITIVITY TO ANTIDEPRESSANTS |
2018 |
- Ikonnikova Anna Yurevna
- Pozhitnova Viktoriya Olegovna
- Nasedkina Tatyana Vasilevna
- Zasedatelev Aleksandr Sergeevich
|
RU2716589C1 |
| SET OF OLIGONUCLEOTIDE PRIMERS AND PROBES FOR GENETIC TYPING OF POLYMORPHOUS DNA LOCI ASSOCIATED WITH A RISK OF PROGRESSION OF SPORADIC FORM OF ALZHEIMER'S DISEASE IN RUSSIAN POPULATIONS |
2014 |
- Nasedkina Tatyana Vasilevna
- Gra Olga Alekseevna
- Nizamutdinov Igor Igorevich
- Zasedatelev Aleksandr Sergeevich
|
RU2600874C2 |
| METHOD FOR DETERMINING GENETIC MARKERS FOR ASSESSING POLYGENIC RISK OF DEVELOPING HORMONE-POSITIVE SUBTYPE OF BREAST CANCER |
2020 |
- Ikonnikova Anna Yurevna
- Nasedkina Tatyana Vasilevna
|
RU2753002C1 |
| METHOD FOR IDENTIFICATION OF GENETIC POLYMORPHISMS AFFECTING METABOLISM OF ANTICANCER DRUGS USING BIOLOGICAL MICROCHIPS |
2018 |
- Gejdarov Rustam Nuraddin Ogly
- Mikhajlovich Vladimir Mikhajlovich
- Popov Anatolij Yurevich
- Titov Sergej Vladimirovich
- Emelyanova Marina Aleksandrovna
- Shaskolskij Boris Leonidovich
- Zasedatelev Aleksandr Sergeevich
|
RU2697096C1 |
| METHOD FOR DETERMINING GENETIC MARKERS FOR ASSESSING POLYGENIC RISK OF BREAST CANCER (HORMONE-NEGATIVE AND HORMONE-POSITIVE SUBTYPES) |
2020 |
- Ikonnikova Anna Yurevna
- Nasedkina Tatyana Vasilevna
- Zasedatelev Aleksandr Sergeevich
|
RU2749465C1 |
| METHOD FOR ANALYSING GENETIC POLYMORPHISM FOR DETERMINING DISPOSITION TO SCHIZOPHRENIA AND ALCOHOLISM |
2012 |
- Nasedkina Tat'Jana Vasil'Evna
- Gra Ol'Ga Alekseevna
- Nizamutdinov Igor' Igorevich
- Galaktionova Dar'Ja Jur'Evna
- Lysov Jurij Petrovich
- Zasedatelev Aleksandr Sergeevich
|
RU2565036C2 |
| BIOLOGICAL MICROCHIP WITH PRIMER SET FOR ANALYSIS OF POLYMORPHISM IN AB0, HLA-DQA1, AMEL, DARC, NAT2 GENES |
2014 |
- Fesenko Denis Olegovich
- Kornienko Aleksandra Evgenevna
- Nasedkina Tatjana Vasilevna
- Zasedatelev Aleksandr Sergeevich
|
RU2582216C2 |
| METHOD FOR IDENTIFYING CHROMOSOMAL TRANSLOCATIONS LEADING TO THE DEVELOPMENT OF MALIGNANT BLOOD DISEASES (LEUKOSES), DUE TO APPLYING OLIGONUCLEOTIDE BIOLOGICAL MICROCHIP (BIOCHIP) |
2004 |
- Mirzabekov Andrej Dar'Evich
- Nasedkina Tat'Jana Vasil'Evna
- Zharinov Vladislav Sergeevich
- Isaeva Ekaterina Aleksandrovna
|
RU2286798C2 |
| METHOD FOR ANALYSIS OF GENETIC POLYMORPHYSM, DEFINING PREDISPOSITION TO TUMOR DISEASES AND INDIVIDUAL SENSITIVITY TO PHARMACEUTICAL AGENTS BY USING OLYGONUCLEOTIDE BIOLOGICAL MICROARRAY (BIOARRAY) |
2005 |
- Zasedatelev Aleksandr Sergeevich
- Nasedkina Tat'Jana Vasil'Evna
- Glotov Andrej Sergeevich
|
RU2303634C2 |
