METHOD FOR DETERMINING POLYMORPHIC MARKERS IN SLCO1B1, APOE AND ABCB1 GENES FOR DETERMINING INDIVIDUAL SENSITIVITY TO STATINS Russian patent published in 2019 - IPC G01N33/543 G01N33/58 C12Q1/6876 

Abstract RU 2695783 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention refers to pharmacogenetics and personalized medicine. Disclosed is a method of analysing polymorphous markers in the SLCO1B1, APOE and ABCB1 genes to determine individual sensitivity to statins, comprising the following steps: amplification by multiplex single-step PCR, providing a biochip, hybridising the fluorescent labeled PCR product on the biochip and recording and interpreting the hybridisation results.

EFFECT: invention provides detecting the following polymorphous markers: SLCO1B1 (rs4149056, rs4149015), APOE (rs7412), ABCB1 (rs2032582).

1 cl, 2 dwg, 2 tbl, 4 ex

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RU 2 695 783 C1

Authors

Ikonnikova Anna Yurevna

Nasedkina Tatyana Vasilevna

Zasedatelev Aleksandr Sergeevich

Dates

2019-07-26Published

2018-12-28Filed