METHOD FOR ANALYSING GENETIC POLYMORPHISM FOR DETERMINING DISPOSITION TO SCHIZOPHRENIA AND ALCOHOLISM Russian patent published in 2015 - IPC C12Q1/68 A61P25/18 A61P25/32 

Abstract RU 2565036 C2

FIELD: medicine.

SUBSTANCE: invention refers to genetics and molecular biology and concerns a method for analysing a genetic polymorphism in polymorphous gene points. The characterised invention involves genetic typing of loci responsible for the disposition to schizophrenia and alcoholism by means of the DNA-biochip technology and a kit of agents. The invention makes it possible to determine the base composition in ten polymorphous positions: HTR2A (rs6311, rs6314, rs7997012), BDNF (rs6265), DISC1 (rs3737597), ZNF804A (rs1344706), RELN (rs7341475), COMT (rs165599), SLC18A (rs2270641), PLXNA2 (rs1327175), ADH1B (rs1229984, rs1042026), ALDH2 (rs671), DRD2 (rs1800497, rs1799732), COMT (rs4680), NPY (rs16139), ADH1C (rs1693482), NKR1 (rs6715729) and AUTS2 (rs6943555), that in turn enables characterising the potential disposition to schizophrenia and alcoholism.

EFFECT: invention enables simplifying the analysis procedure of the genetic polymorphism for determining the disposition to schizophrenia and alcoholism.

3 cl, 3 dwg, 4 tbl, 2 ex

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RU 2 565 036 C2

Authors

Nasedkina Tat'Jana Vasil'Evna

Gra Ol'Ga Alekseevna

Nizamutdinov Igor' Igorevich

Galaktionova Dar'Ja Jur'Evna

Lysov Jurij Petrovich

Zasedatelev Aleksandr Sergeevich

Dates

2015-10-10Published

2012-05-04Filed