FIELD: chemistry.
SUBSTANCE: invention relates to methylphenidate prodrugs, in which methylphenidate is conjugated with at least one tertiary amine and oxoacid.
EFFECT: prodrugs possess increased water-solubility and bioavailability in comparison with non-modified methylphenidate 
.
9 cl, 30 dwg, 5 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE | 2015 |
|
RU2683317C2 |
| BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS FOR PRODUCING AND USING THEM | 2012 |
|
RU2573388C2 |
| CONJUGATES OF HYDROCODONE WITH BENZOIC ACID, DERIVATIVES OF BENZOIC ACID AND HETERO-ACRYL-CARBON ACID, PRODRUGS, METHODS FOR THEIR OBTAINING AND APPLICATION | 2010 |
|
RU2505541C2 |
| BENZOIC ACID, BENZOIC ACID DERIVATIVES AND CONJUGATES OF HETEROARYL CARBOXYLIC ACID AND OXYMORPHONE, PRODRUGS, METHODS FOR OBTAINING AND USE THEREOF | 2015 |
|
RU2683274C2 |
| CONJUGATES: THERAPEUTIC COMPOUND-FATTY ACID | 1994 |
|
RU2137755C1 |
| PRODRUGS CONTAINING EXENDIN CONJUGATE-LINKER | 2011 |
|
RU2593774C2 |
| PRODRUGS CONTAINING INSULIN LINKER CONJUGATE | 2010 |
|
RU2574667C2 |
| CONJUGATES OF LIGAND AND DRUGS | 2006 |
|
RU2470668C2 |
| DERIVATIVES OF VITAMINE B6 NUCLEOTIDES, ACYCLIC NUCLEOTIDES AND ACYCLIC NUCLEOSIDE PHOSPHONATES | 2012 |
|
RU2640582C2 |
| TARGETED CONJUGATES AND PARTICLES AND COMPOSITIONS THEREOF | 2015 |
|
RU2695220C2 |
