NEW CRYSTAL SOLID COMPOUND OF 3-PHENYL-4-PROPYL-1-(PYRIDINE-2-YL)-1H-PYRAZOL-5-OL HYDROCHLORIDE Russian patent published in 2021 - IPC C07D401/04 A61K31/4439 A61P13/12 A61P19/10 A61P27/02 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for producing a crystal compound of 3-phenyl-4-propyl-1-(pyridine-2-yl)-1H-pyrazole hydrochloride. The method is carried out by a) reacting ethyl ether of 2-propyl-3-oxo-3-phenylpropionic acid with 2-hydrazinopyridine to obtain an unrefined product; b) dissolving the unrefined product in normal hexane and then slowly cooling the resulting solution to from -20 to -10°C to obtain solid substance; c) filtering, washing and drying the resulting solid substance to obtain a non-crystal compound of a free base; d) adding the non-crystal compound of a free base to a mixed solvent containing acetonitrile and distilled water in the same amount, and active mixing the resulting mixture at from 20 to 25°C to obtain crystal substance; e) filtering, washing and drying the resulting crystal substance to obtain a crystal compound of a free base, represented by the Formula 2; f) interacting of the crystal compound of a free base with a solution of hydrochloric acid – isopropyl ether to obtain solid substance of hydrochloride; g) adding solid substance of hydrochloride to a mixed solvent containing tert-butyl ether and toluene in the same amount, and active mixing the resulting mixture at from 5 to 10°C to obtain crystal substance; and h) filtering, washing and drying the resulting crystal substance to obtain a crystal compound of hydrochloride, represented by the following Formula 1.

EFFECT: technical result is the production of 3-phenyl-4-propyl-1-(pyridine-2-yl)-1H-pyrazole hydrochloride in a crystal form with stability and a lower concentration of impurities.

[Formula 2]

[Formula 1]

1 cl, 8 dwg, 5 tbl, 4 ex