FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, namely to a composition that inhibits MEIS proteins that are effective in the proliferation of hematopoietic stem cells. The composition contains a MEISi inhibitor, which represents MEISi-1 or MEISi-2, cells obtained as a result of isolation, a nutrient medium, and a growth factor. The composition can easily pass through the cell membrane and show its activity in the cell and can inhibit the activity of MEIS in dose-dependent manner. The composition can induce ex vivo reproduction of hematopoietic stem cells of mouse, human umbilical cord blood and human bone marrow.
EFFECT: application of the present invention in vivo triggers the reproduction of hematopoietic stem cells in the bone marrow and peripheral blood.
8 cl, 1 tbl, 10 dwg
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| METHOD TO STIMULATE EXPANSION OF HAEMATOPOIETIC STEM CELLS | 2007 |
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| METHOD OF TREATING RETINOPATHY IN PREMATURITY AND RELATED RETINOPATHIC DISEASES | 2006 |
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RU2403906C2 |
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| METHOD FOR COMBINED CONDITIONING AND HEMOSELECTION IN ONE CYCLE | 2012 |
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RU2611396C2 |
| STEM CELL PROLIFERATION INHIBITOR AND STIMULANT AND USAGE THEREOF | 1997 |
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