METHOD TO STIMULATE EXPANSION OF HAEMATOPOIETIC STEM CELLS Russian patent published in 2013 - IPC C12N5/71 C12N5/22 A61K35/14 

FIELD: biotechnologies.

SUBSTANCE: method is described to stimulate expansion of haematopoietic stem cells (HSC) in vitro or in vivo. A population of cells is incubated, which contains HSC, in presence of at least one HSC modulator, at the same time the HSC modulator is selected from the group that consists of PGE2, PGI2, linoleic acid, 13(s)- HODE, L Y 171883, MIDA acid, eicosatrienoic acid, epoxyeicosatrienoic acid, ONO-259, Cay 1039, an agonist of receptor PGE2, 16,16-dimethyl-PCE2, 19(R)-hydroxy-PCE2, n-(n-acetamide benzamide)phenyl esther 16,16-dimethyl-PCE2, 11-desoxy-16,16-dimethyl-PCE2, 9-desoxy-9-methylene-16,16-dimethyl-PCE2, 9-desoxy-9-methylene-POE2, butaprost, sulprostone, serynolamide PGE2, methyl ester PGE2, 16-phenyltetranor-POE2, 15(S)-15-MeTnn-PGE2 and 15(R)-15-MeTnn-PGE2. A method is proposed to strength HSC acceptance, and also a method to strengthen recovery of haematopoietic stem cells, which include HSC incubation in presence of at least one HSC modulator.

EFFECT: invention expands arsenal of methods for stimulation of growth of haematopoietic stem cells in a subject.

28 cl, 24 dwg, 11 tbl, 2 ex