FIELD: biotechnology.
SUBSTANCE: group of inventions relates to a modified microorganism producing a mycosporine-like amino acid (MAA) and to a method for producing a MAA using said microorganism. Proposed is a modified microorganism intended for producing a mycosporine-like amino acid, wherein the mycosporine-like amino acid constitutes a compound with a central ring of cyclohexanone or cyclohexenimine. The microorganism therein expresses a cluster of MAA biosynthesis genes, and wherein the activity of at least one protein selected from the group consisting of 2-dehydro-3-deoxyphosphoheptonate aldolase (AroG), phosphoenolpyruvate synthetase (Pps) and transketolase (TktA) is modified to enhance by means of introduction of a gene encoding said at least one protein into the microorganism expressing a cluster of MAA biosynthesis genes. The microorganism therein demonstrates an increased production of a mycosporine-like amino acid compared to the parent or unmodified microorganism without said modification, expressing only a cluster of MAA biosynthesis genes. Also proposed is a method for producing a mycosporine-like amino acid, including cultivation of the described modified microorganism in a medium and isolation of a mycosporine-like amino acid from the cultured microorganism or medium.
EFFECT: group of inventions can be efficiently used in production of a mycosporine-like amino acid.
7 cl, 27 tbl, 19 ex
Title |
Year |
Author |
Number |
MICROORGANISM FOR PRODUCING MYCOSPORINE-LIKE AMINO ACID AND A METHOD OF OBTAINING MYCOSPORINE-LIKE AMINO ACID USING IT |
2018 |
- Kim Sol
- Lee Kyusung
- Lee Joo Hee
- Seok Jong-Cheol
- Jang Jae Woo
|
RU2736362C1 |
MICROORGANISM FOR PRODUCING L-AMINO ACID WITH HIGH ACTIVITY OF Α-GLUCOSIDASE AND METHOD OF PRODUCING L-AMINO ACID USING THEREOF |
2019 |
- Kim Kyungrim
- Byun Hyo Jeong
- Lee Kwang Woo
- Kim Hyung Joon
- Shin Yong Uk
|
RU2732338C1 |
MICROORGANISM OF CORYNEBACTERIUM GENUS, PRODUCING L-AMINO ACIDS, AND METHOD OF PRODUCING L-AMINO ACIDS USING SAME |
2022 |
- Lee Han Hyoung
- Byun Hyo Jeong
- Kim Byeong Soo
- Kim Hee Ju
- Jung Moo Young
- Kim Hyung Joon
- Park Seul-Gi
|
RU2824668C1 |
VARIANT OF ACETOHYDROXY ACID SYNTHASE, MICROORGANISM CONTAINING SAME, AND METHOD FOR PRODUCING AMINO ACID WITH 1ST BRANCHED CHAIN |
2018 |
- Jeon Ae Ji
- Song Byeong Cheol
- Lee Ji Hye
- Kim Jong Hyun
- Kim Hye Won
|
RU2743964C1 |
NEW O-SUCCINYL HOMOSERINE TRANSFERASE VARIANT AND METHOD FOR SYNTHESIS OF O-SUCCINYL HOMOSERINE USING SAID VARIANT |
2018 |
- Kim Kyungrim
- Shim Jihyun
- Kim Hyun Ah
- Shin Yong Uk
- Lee Peter
|
RU2747493C1 |
NEW O-SUCCINYL HOMOSERINE TRANSFERASE MUTANT AND METHOD FOR SYNTHESIS OF O-SUCCINYL HOMOSERINE USING SAID MUTANT |
2018 |
- Kim Kyungrim
- Shim Jihyun
- Kim Hyun Ah
- Shin Yong Uk
- Lee Peter
|
RU2747494C1 |
MICROORGANISMS FOR PRODUCING ORNITHINE AND METHOD OF PRODUCING ORNITHINE USING SAID MICROORGANISMS |
2016 |
- Park Su Jin
- Yang Young Lyeol
- Um Hye Won
- Li Hong Xian
- Lee Kyoung Min
- Lee Baek Seok
- Lee Hyo Hyoung
- Jung Hee Kyoung
|
RU2721852C1 |
MICROORGANISM PRODUCING PUTRESCINE OR ORNITHINE AND METHOD FOR PRODUCING PUTRESCINE OR ORNITHINE USING THIS MICROORGANISM |
2016 |
- Jung Hee Kyoung
- Um Hye Won
- Li Hong Xian
- Park Su Jin
- Yang Young Lyeol
- Lee Kyoung Min
- Lee Hyo Hyoung
|
RU2759956C1 |
VARIANT OF GENUS YARROWIA AND METHOD OF PRODUCING FAT USING SAME |
2021 |
- Jang Jiryang
- Lee Peter
- Bae Jee Yeon
- Kim Ju-Yeon
- Park Hye Min
- Kim Hyung Joon
- Park Sang Min
|
RU2817101C1 |
O-SUCCINYL HOMOSERINE-PRODUCING MICROORGANISM AND METHOD OF PRODUCING O-SUCCINYL HOMOSERINE USING THEREOF |
2015 |
- Choi, Su Jin
- Hong, Kuk Ki
- Yang, Young Lyeol
- Kang, Min Sun
- Park, Hye Min
- Song, Gyuhyeon
- Yoon, Jong Hyun
|
RU2723183C2 |