FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, namely to a genetically recombinant smallpox vaccine virus that is effective for the prevention or treatment of cancer. The smallpox vaccine virus contains two polynucleotides, polynucleotide encoding IL-7 and encoding IL-12. The virus has oncolytic activity. The pharmaceutical composition contains the smallpox vaccine virus and is used for the prevention or treatment of cancer.
EFFECT: smallpox vaccine virus causes complete remission and acquired immunity.
15 cl, 8 dwg, 8 tbl, 8 ex
| Title |
Year |
Author |
Number |
| CANCER THERAPY BY COMBINED USE OF ONCOLYTIC SMALLPOX VACCINE VIRUS AND IMMUNE CONTROL POINT INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND COMBINED DRUG FOR USE IN CANCER THERAPY |
2019 |
- Nakao Shinsuke
- Kawase Tatsuya
|
RU2788874C2 |
| ENHANCER OF T-CELLS OR B-CELLS WITH MEMORY FUNCTION, INHIBITOR OF CANCER RECURRENCE AND INDUCER FOR INDUCING MEMORY FUNCTION IN T-CELLS OR B-CELLS |
2018 |
- Tamada Koji
- Sakoda Yukimi
- Adachi Keishi
- Nakamura Takafumi
|
RU2802824C2 |
| VECTORS CONDITIONALLY EXPRESSING THERAPEUTIC PROTEINS, HOST CELLS COMPRISING THE VECTORS, AND USES THEREOF |
2011 |
|
RU2612788C2 |
| RECOMBINANT VESICULAR STOMATITIS VIRUS EXPRESSING CHIMERIC IL12-GMCSF PROTEIN |
2022 |
- Karabelskij Aleksandr Vladimirovich
- Ivanov Roman Alekseevich
- Ulitin Andrej Borisovich
|
RU2817896C1 |
| VACCINE ONCOLYTIC VERSION AND METHODS OF ITS USE |
2020 |
- Abbadessa, Darin Michael
- Maruri Avidal, Liliana
- Gulizia, Nathaniel Phillip
- Kirn, David H.
- Kotterman, Melissa A.
- Slaby, Todd Brandon
|
RU2805179C1 |
| ONCOLYTIC VIRUS FOR IMMUNOLOGIC CONTROL POINT MODULATORS EXPRESSION |
2015 |
- Silvestr Natali
- Gejst Mishel
- Rittner Karola
- Marshan Zhan-Batist
- Tiudelle Kristin
|
RU2696312C2 |
| VIRAL VECTOR MANUFACTURE |
2014 |
|
RU2658487C2 |
| PRODUCTION OF POX VIRUSES AND COMPOSITION OF POX VIRUSES |
2013 |
- Malarme Danel
- Korde Iv
- Sene Klod
|
RU2581910C2 |
| COMBINATION OF ONCOLYTIC VIRUS WITH MODULATORS OF IMMUNOLOGICAL CONTROL POINTS |
2015 |
- Tsitfogel Lorans
- Previll Ksave
- Fend Letitsiya
|
RU2705780C2 |
| VIRAL VACCINES |
2017 |
|
RU2778312C2 |
