FIELD: biotechnology; genetic engineering.
SUBSTANCE: present invention relates to the field of biotechnology and genetic engineering, in particular to methods for cell transduction. To implement methods, a set of target cells is incubated with a soluble oligomer reactive and a virus particle. The soluble oligomer reactive contains oligomer or polymer of at least three tetramers of streptavidin mutein. As a result, an output composition is obtained containing cells transduced with the virus particle.
EFFECT: present invention allows improving strategies of cell population transduction in vitro, including for research, diagnostic and therapeutic purposes.
148 cl, 56 dwg, 3 tbl, 23 ex
| Title | Year | Author | Number |
|---|---|---|---|
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| MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR GLYPICAN-3 (GPC3) | 2016 |
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| NOVEL FUSION PROTEIN SPECIFIC FOR CD137 AND PD-L1 | 2019 |
|
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| ANTI-IDIOTYPIC ANTIBODIES AND METHODS RELATED TO THEM | 2017 |
|
RU2773355C2 |
