FIELD: biotechnology.
SUBSTANCE: oligomeric reagent is presented, including oligomeric reagents of streptavidin or streptavidin mutein, where oligomeric reagents in the form of particles contain a set of agent binding sites, which are multimerized by reversible binding to the oligomeric reagent in the form of particles, thus creating a multimerized oligomeric reagent in the form of particles, having stimulating agents multimerized on it. A method for stimulation of cells is also presented, wherein the method includes incubation of a cell composition containing target cells in the presence of the multimerized oligomeric reagent in the form of particles.
EFFECT: invention allows for the production of reagents of a cell culture with improved characteristics for the stimulation of a cell population and further use in adoptive cell immunotherapy or anticancer therapy.
80 cl, 15 dwg, 5 tbl, 6 ex
| Title | Year | Author | Number |
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