FIELD: biotechnology.
SUBSTANCE: group of inventions relates to the field of biotechnology, in particular to immunoglobulin conjugates. The invention allows one, during an enzymatic reaction catalyzed with microbial transglutaminase, to obtain a conjugate of lysine containing a modified or mutant residue in a constant region of immunoglobulin with a functional means containing acyl-donor substrate with glutamine residue.
EFFECT: use of the site-specific enzymatic reaction for combining fragments of an antibody and functional means within a single molecule allows for obtaining antibody-drug conjugates (ADC conjugates) with a relatively homogenous indicator of distribution of antibody-drug relations (DAR).
11 cl, 10 ex, 9 tbl, 12 dwg
| Title |
Year |
Author |
Number |
| POLYVALENT AND POLYSPECIFIC GITR-BINDING FUSED PROTEINS |
2016 |
- Timmer Dzhon K.
- Dzhons Kajl S.
- Razai Amir S.
- Khussejn Abrakhim
- Villis Ketlin M.
- Devero Kuinn
- Ekelman Brendan P.
|
RU2753439C2 |
| MOLECULES TARGETING A TYPE III SECRETION SYSTEM |
2016 |
- Khollands, Endryu
- Timmer, Dzhon K.
- Devero, Kuinn
- Ekelman, Brendan P.
|
RU2759949C2 |
| PSEUDO-FAB BASED MULTISPECIFIC BINDING PROTEINS |
2019 |
- Weil, Sandra
- Rao, Ercole
- Leuschner, Wulf-Dirk
- Langer, Thomas
- Hoelper, Soraya
- Engel, Karl-Christian
- Beil, Christian
- Hessler, Gerhard
- Lange, Christian
- Lemoine, Cendrine
- Oezguer Bruederle, Sevim
- Spindler, Nadja
|
RU2820254C2 |
| VARIANTS OF FC-REGION WITH MODIFIED ABILITY TO BIND TO FCRN AND WITH PRESERVED ABILITY TO BIND WITH PROTEIN A |
2015 |
- Shkolaut Aleksander
- Shlotauer Tilman
|
RU2727639C2 |
| RECOVERED ANTIBODY (VERSIONS), A METHOD FOR PRODUCING THE ANTIBODY, AN ISOLATED NUCLEIC ACID, AN EXPRESSION CASSETTE (VERSIONS), A PLASMID (VERSIONS), A HOST CELL, A PHARMACEUTICAL PREPARATION, A KIT, A METHOD OF TREATING A PATIENT, AT RISK OF OR SUFFERING FROM ESCHERICHIA COLI INFECTION, AND A DIAGNOSTIC TECHNIQUE FOR DETERMINING ESCHERICHIA COLI INFECTIONS |
2014 |
- Vaskes Maksimiliano
- Gvchalya Luis
- Nad Gabor
- Nad Ester
- Sijyarto Valeriya
|
RU2724530C2 |
| VERSIONS OF THE FC-DOMAIN WITH MODIFIED ABILITIES TO BIND TO FCRN |
2015 |
|
RU2730592C2 |
| METHOD OF PURIFICATION FOR REMOVING TYROSINE SULPHATED ANTIBODIES VARIANTS, PURIFIED COMPOSITIONS |
2017 |
- Chzhao, Tszya
- Rajos, Sandra
- Shyussler, Svetlana Dukleska
|
RU2793400C2 |
| PROTEIN BINDING WITH NKG2D, CD16 AND WITH TUMOR-SPECIFIC ANTIGEN |
2018 |
- Chang, Gregory P.
- Cheung, Ann F.
- Haney, William
- Lunde, Bradley M.
- Prinz, Bianka
|
RU2788531C2 |
| HIGH-AFFINITY ANTI-PD-1 AND ANTI-LAG-3 ANTIBODIES AND BISPECIFIC BINDING PROTEINS OBTAINED FROM THEM |
2019 |
- Wu, Xuan
- Gong, Shiyong
- Wu, Chengbin
|
RU2782381C2 |
| CRYOPRESERVED CELLS ARE NATURAL KILLERS PRELOADED WITH ANTIBODY CONSTRUCTION |
2019 |
- Rojsh, Uve
- Kokh, Joakhim
- Treder, Martin
- Dulat, Kholger J.
|
RU2819927C2 |
