FIELD: biotechnology.
SUBSTANCE: there are presented: binding and multispecific binding proteins, which bind target antigen, where VHX contains one or more inactivating mutations Y33A, R50E, R59E and Y105A and/or cysteine substitution G44C and/or VLX contains cysteine substitution Q100C, methods for production and use thereof. Also disclosed are nucleic acid molecules, expression vectors, host cells and pharmaceutical compositions containing them.
EFFECT: group of inventions is used to treat disorders in which antigen activity has a negative effect on the body, in particular oncological diseases.
43 cl, 12 tbl, 18 dwg, 10 ex
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