FIELD: medicine; pharmacology.
SUBSTANCE: invention is intended for functionalisation of calcium phosphate preparation with preparation of cisplatin in water solution. Calcium phosphate material used is octacalcium phosphate (OCP), and to prolong the release of the chemotherapeutic drug, zoledronic acid is added to the cisplatin solution at a weight ratio of 0.2:1 to 1:1, respectively.
EFFECT: use of the invention provides delivery of cisplatin to a given area, for example, in a bed of a tumor removed in bone tissue, in combination with bone defect replacement with calcium phosphate material with osteoinductive properties, which leads to a decrease in the general toxicity of cisplatin and its saving, and also provides a prolonged therapeutic effect and bone tissue regeneration.
1 cl, 4 dwg, 1 tbl, 1 ex
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