METHOD FOR TREATMENT OF PATIENTS WITH GASTRIC CANCER WITH LIMITED PERITONEAL CARCINOMATOSIS Russian patent published in 2022 - IPC A61B17/00 A61K31/337 A61K31/282 A61K31/519 A61K31/513 A61K31/704 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology, and can be used to treat gastric cancer patients with limited peritoneal carcinomatosis. The method includes palliative surgery followed by the introduction of cytostatics into the abdominal cavity. After diagnostic laparoscopy and verification of peritoneal carcinomatosis, a phased treatment is carried out. Spend 4 courses of systemic chemotherapy in a combined regimen according to the FLOT scheme every 14 days. 7 days after 4 courses of systemic chemotherapy by laparoscopy, with trocars placed 4-5 cm parumbelically, pneumoperitoneum is reached with a target pressure of 12 mm Hg. and conduct a session of intra-abdominal aerosol chemotherapy at a pressure of 200 psi using antitumor drugs based on anthropometric parameters: cisplatin at a dose of 30 mg/m² diluted in isotonic sodium chloride solution with a volume of 150 ml, doxorubicin 6 mg/m² diluted in isotonic sodium chloride solution with a volume of 50 ml. A week after the operation, an additional 4 courses of systemic chemotherapy are carried out in a combined regimen according to the FLOT scheme every 14 days up to a total of 8 courses. A week later, the second session of intra-abdominal aerosol chemotherapy is repeated: cisplatin at a dose of 30 mg/m², doxorubicin 6 mg/m². 14 days later, after the second session of intra-abdominal aerosol chemotherapy, cytoreduction is performed.

EFFECT: use of the invention provides stable stabilization and partial resorption of tumor foci in incurable patients due to the long-term maintenance of therapeutic pneumoperitoneum and the direct effect of drugs on tumor cells with the maximum concentration in tumor-affected foci without systemic toxicity.

1 cl, 2 dwg, 1 ex