FIELD: immunology.
SUBSTANCE: group of inventions relates to immunology, in particular to a drug of human plasma antibodies and its use in the treatment of an immunological disorder. The antibody drug is suitable for intravenous injection to a human, and it contains from 15% to 30% of all immunoglobulins IgM, from 45% to 70% of all immunoglobulins IgG, and from 15% to 30% of all immunoglobulins IgA. The drug has viral safety relatively to enveloped and non-enveloped viruses, has anticomplementary activity ≤1 CH50/mg of protein, and it is stable in a liquid form during at least 2 years, when stored at 2-8°C, while the antibody drug is not treated with β-propiolactone during its production process.
EFFECT: IgM and IgA-mediated activity in the proposed drug is at least 1.5 times higher compared to IgM and IgA activity in the drug obtained using treatment with β-propiolactone.
14 cl, 10 tbl, 9 ex, 1 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING COMPOSITION OF IMMUNOGLOBULINS | 2011 |
|
RU2612899C2 |
| ANTIBODY PREPARATIONS | 2011 |
|
RU2749732C2 |
| PREPARATIONS OF ANTIBODIES | 2011 |
|
RU2617532C2 |
| METHOD FOR PRODUCING IMMUNOGLOBULIN FOR INTRAVENOUS INTRODUCTION OF IMMUNOGLOBULIN M ENRICHED PREPARATION, AND PREPARATION PREPARED BY SUCH METHOD | 2010 |
|
RU2470664C2 |
| METHOD OF PRODUCING COMPLEX OF IgG, IgM AND IgA IMMUNOGLOBULINS FOR INTRAVENOUS ADMINISTRATION | 2012 |
|
RU2492176C1 |
| METHOD OF IGM-CONTAINING IMMUNOGLOBULIN CONCENTRATE PREPARING | 1999 |
|
RU2158136C1 |
| HUMAN IMMUNOGLOBULIN PREPARATION AGAINST CYTOMEGALOVIRUS FOR INTRAVENOUS INTRODUCTION AND METHOD OF ITS OBTAINING | 2009 |
|
RU2404250C1 |
| METHOD OF PREPARING IMMUNOGLOBULINS FOR INTRAVENOUS ADMINISTRATION AND OTHER IMMUNOGLOBULIN PREPARATIONS | 1999 |
|
RU2197500C2 |
| PREPARATION OF ANTIBODY IgG AND METHOD OF ITS PRODUCTION | 2005 |
|
RU2337109C2 |
| CHIMERIC IMMUNOGLOBULIN PREPARATION WITH SPECIFIC ANTIVIRAL OR ANTIBACTERIAL EFFECT | 2015 |
|
RU2599029C1 |
