COMPOSITE MATRIX FOR CELL IMMOBILIZATION IN A TISSUE-LIKE BIOLOGICAL CELL SYSTEM AND A METHOD OF ITS SPATIAL TRANSFORMATION IN THE PROCESS OF CELL IMMOBILIZATION Russian patent published in 2022 - IPC A61L27/50 

FIELD: tissue engineering and biotechnology.

SUBSTANCE: inventions group relates to the field of tissue engineering and biotechnology and can be used for the cultivation of animal cells as part of bioartificial cell systems for cell technologies, tissue engineering, regenerative medicine, biopharmacology. Liquid-fibrous substrate consisting of a hydrophilized coil of polymer fibers obtained by electrospinning, the fiber diameter is less than 5 mcm, a reinforcing-mesh forming frame made of bioresorbable material with a rod thickness of 200-500 mcm. In this case, a ball of polymer fibers is placed in a culture fluid with suspended cells in the volume covered by the frame elements. By displacement of the elements of the forming framework and/or partial drainage of the culture liquid, the fibers of the liquid-fibrous substrate with immobilized cells are collected until a dense fibrous matrix-cell block is formed.

EFFECT: inventions group provides the achievement of a technical result consisting in the creation of a dense composite matrix from a liquid-fibrous substrate with a forming framework, and a volumetric population of the matrix with animal cells due to a step-by-step process of cell immobilization.

7 cl, 10 dwg