COMPOSITE MATRIX FOR CELL IMMOBILIZATION IN A TISSUE-LIKE BIOLOGICAL CELL SYSTEM AND A METHOD OF ITS SPATIAL TRANSFORMATION IN THE PROCESS OF CELL IMMOBILIZATION Russian patent published in 2022 - IPC A61L27/50 

Abstract RU 2765927 C1

FIELD: tissue engineering and biotechnology.

SUBSTANCE: inventions group relates to the field of tissue engineering and biotechnology and can be used for the cultivation of animal cells as part of bioartificial cell systems for cell technologies, tissue engineering, regenerative medicine, biopharmacology. Liquid-fibrous substrate consisting of a hydrophilized coil of polymer fibers obtained by electrospinning, the fiber diameter is less than 5 mcm, a reinforcing-mesh forming frame made of bioresorbable material with a rod thickness of 200-500 mcm. In this case, a ball of polymer fibers is placed in a culture fluid with suspended cells in the volume covered by the frame elements. By displacement of the elements of the forming framework and/or partial drainage of the culture liquid, the fibers of the liquid-fibrous substrate with immobilized cells are collected until a dense fibrous matrix-cell block is formed.

EFFECT: inventions group provides the achievement of a technical result consisting in the creation of a dense composite matrix from a liquid-fibrous substrate with a forming framework, and a volumetric population of the matrix with animal cells due to a step-by-step process of cell immobilization.

7 cl, 10 dwg

Similar patents RU2765927C1

Title Year Author Number
METHOD OF PRODUCING THREE-DIMENSIONAL MATRICES FOR TISSUE-LIKE STRUCTURES FROM ANIMAL CELLS 2008
  • Gorjukhina Ol'Ga Aleksandrovna
  • Martjushin Sergej Vasil'Evich
  • Pinaev Georgij Petrovich
RU2396342C1
THREE-DIMENSIONAL BIOACTIVE CARRIER FOR MAMMALIAN CELLS AND TISSUES CULTIVATION 1992
  • Radjukhin V.A.
  • Golubkov S.P.
  • Zinov'Ev V.V.
  • Kokorevskaja O.A.
RU2014359C1
METHOD FOR PRODUCING IMMOBILIZED BACTERIAL CELL PREPARATION WITH AMYLASE AND LIPASE ACTIVITY 2022
  • Maksimov Aleksandr Iurevich
  • Maksimova Iuliia Gennadevna
RU2804526C1
METHOD OF IMMOBILISED OSTEOGEN STROMAL BONE MARROW STEM CELL 2006
  • Ostanin Aleksandr Anatol'Evich
  • Khejfets Mikhail Vladimirovich
  • Sizikov Mikhail Jur'Evich
  • Stupak Vjacheslav Vladimirovich
  • Chernykh Elena Removna
RU2329055C2
METHOD FOR MICROORGANISM CELLS IMMOBILIZATION 0
  • Donova Marina Viktorovna
  • Markvicheva Elena Arnoldovna
  • Kuzkina Irina Fedorovna
  • Kuznetsov Aleksej Ivanovich
  • Baklashova Tatyana Grigorevna
  • Koshcheenko Kira Aleksandrovna
  • Kirsh Yurij Erikhovich
  • Karaputadze Timur Musaevich
  • Simakova Galina Aleksandrovna
  • Gritskova Inessa Aleksandrovna
  • Zubov Vitalij Pavlovich
  • Pashkin Igor Ivanovich
SU1687615A1
TWO-LAYER, FLAT, TRANSPARENT HYDROGEL SUBSTRATE FOR LONG-TERM CELL CULTIVATION 2016
  • Osidak Egor Olegovich
  • Sivogrivov Dmitrij Evgenevich
  • Domogatskaya Anna Sergeevna
  • Domogatskij Sergej Petrovich
  • Osidak Mariya Sergeevna
RU2614260C1
CRYOPRESERVATION METHOD OF CELLS OF PHOTOTROPHIC MICROORGANISMS 2012
  • Efremenko Elena Nikolaevna
  • Sen'Ko Ol'Ga Vital'Evna
  • Makhlis Tat'Jana Abramovna
  • Mamedova Fakhrija Takhir Kyzy
  • Kholstov Aleksandr Viktorovich
  • Varfolomeev Sergej Dmitrievich
RU2508397C1
IMMOBILIZED BIOACATALYST FOR BACTERIAL CELLULOSE PRODUCTION 2016
  • Efremenko Elena Nikolaevna
  • Stepanov Nikolaj Alekseevich
  • Senko Olga Vitalevna
  • Maslova Olga Vasilevna
RU2636041C2
BIOCOMPOSITES AND METHODS FOR MAKING THEM 2009
  • Paukshto Mikhail Vitol'Dovich
  • Makmartri Dehvid Kharvud
  • Martin Georg R.
  • Zajtseva Tat'Jana
  • Bobrov Jurij Aleksandrovich
RU2500432C2
CELL CULTURE MATRIX 2014
  • Rakhmatullin Ramil' Rafailevich
  • Burlutskaja Ol'Ga Ivanovna
  • Burtseva Tat'Jana Ivanovna
RU2571215C2

RU 2 765 927 C1

Authors

Nedoseev Sergej Leonidovich

Zaitov Leonid Makhmutovich

Shepelev Aleksej Dmitrievich

Mamagulashvili Vissarion Georgievich

Sedush Nikita Gennadevich

Lukanina Kseniya Igorevna

Chvalun Sergej Nikolaevich

Tenchurin Timur Khasyanovich

Grigorev Timofej Evgenevich

Dates

2022-02-04Published

2021-04-30Filed