FIELD: medicine; pharmaceutics.
SUBSTANCE: present invention provides an oral oil-free super-supersaturated self-emulsifying drug delivery system (SNEDDS) for pharmaceutical compositions containing hydrophobic natural active pharmaceutical ingredients (API), emulsifiers/co-solvents and a stabilized aqueous phase. According to the present invention, SNEDDS demonstrates improved drug loading capacity, self-emulsification, improved stability and bioavailability. There are also presented methods for preparing oral super-saturated self-emulsifying pharmaceutical compositions in liquid and solid forms.
EFFECT: invention discloses a system for the delivery of supersaturated self-nanoemulsifiable drugs (SNEDDS) for poorly water-soluble pharmaceutical compositions and a method for preparing it.
9 cl, 18 dwg, 5 tbl, 6 ex
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