METHOD FOR MANUFACTURING AND INCREASING EFFICIENCY OF MEDICAL GENERATOR OF STRONTIUM-82 / RUBIDIUM-82 Russian patent published in 2022 - IPC G21G4/08 G21G1/04 

FIELD: medicine.

SUBSTANCE: invention relates to products for nuclear medicine, particularly to making isotope generators. Strontium-82/rubidium-82 generator includes a generator column with a sorbent based on hydrated tin oxide (IV), on which radioactive ⁸²Sr isotope is deposited. ⁸²Sr decomposes into short-lived ⁸²Rb (half-life 76 s). In this generator, the maximum volume of the obtained eluate with ⁸²Rb with content of ⁸²Sr and ⁸⁵Sr below permissible level (0.01 and 0.1 kBq per 1 MBq of 82 Rb, respectively) depends on the concentration of ions of stable isotopes of calcium (C_Ca) and strontium (C_Sr) on sorbent, supplied during preparation and use of generator. Obtaining more than 17 l of eluate with allowable content of ⁸²Sr and ⁸⁵Sr is achieved when this ratio is below 0.67 mcmol per 1 g of dry sorbent. Limits for the amount of calcium and strontium to the sorbent when making the generator are proportional to the weight of the sorbent in the column. Thus, at a sufficiently low concentration of calcium and strontium ions and with a sorbent weight in the column of more than 3.8 g, a larger volume of radiopharmaceutical - ⁸²Rb chloride solution with the required characteristics - can be obtained using the generator.

EFFECT: invention makes it possible to more reliably prevent ingress of radioactive strontium isotopes into the patient.

6 cl, 5 dwg, 2 tbl