FIELD: biotechnology.
SUBSTANCE: canine influenza virus is proposed, containing a polynucleotide encoding a hemagglutinin (HA) protein containing the amino acid sequence under the following SEQ ID NO: 62 and the following SEQ ID NO: 78, or its mature form, in which the N-terminal 16 amino acids are removed from the above, or a sequence that is more than 95% identical to the sequence of the mature form, where the indicated mature HA protein contains Ser at amino acid sequence position 82, Leu at 221, Thr at 327 and Thr at 482. Also a vaccine containing an effective amount of canine influenza virus is provided. Besides, a method of inducing an immune response in animals against canine influenza virus by administering an effective amount of the said virus or vaccine is provided.
EFFECT: inventions allow to provide effective treatment of influenza virus infection in canines.
16 cl, 7 dwg, 57 tbl, 25 ex
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