FIELD: biotechnology.
SUBSTANCE: compositions for the expression regulation in order to regulate the expression of a duplicated gene and their application method are described. Compositions for expression regulation include guiding nucleic acid capable of targeting a transcription regulation region of the duplicated gene. A method for regulating the expression of a duplicated gene by artificially changing and/or modifying the transcription regulation region of the duplicated gene is also described. In addition, the present invention relates to a method for the treatment or attenuation of a disease caused by gene duplication using an expression regulation composition in order to regulate the expression of a duplicated gene.
EFFECT: invention expands the arsenal of means for regulating gene expression.
14 cl, 25 dwg, 10 tbl, 7 ex
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