FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, in particular to an artificially modified immune system having an increased immune effect. The invention allows for producing an immune cell with modified functions, containing modified immunoregulatory genes DGKα and DGKζ.
EFFECT: invention has increased therapeutic efficiency compared to known analogues; it can be used in medicine, in particular in adoptive immunotherapy.
17 cl, 8 ex, 6 tbl, 18 dwg
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