ARTIFICIAL MOLECULES OF NUCLEIC ACID Russian patent published in 2020 - IPC C12N15/67 C12Q1/68 

FIELD: biotechnology.

SUBSTANCE: invention describes an artificial nucleic acid molecule for genetic therapy or genetic vaccination, comprising at least one open reading frame (ORF) coding a therapeutic peptide; and at least one 3'-untranslated region (3'-UTR) element, which contains a nucleotide sequence derived from 3'-UTR of the ribosomal protein gene or from the functional version of 3'-UTR of the ribosomal protein gene, wherein said functional variant is at least 80 % identical to said 3'-UTR gene of ribosomal protein; and 5'-untranslated region (5'-UTR), as additional 5'-end of element, where 5'-UTR is 5'TOP-UTR, which does not contain 5'-TOR motive. Application describes an artificial nucleic acid molecule containing at least one open reading frame and at least one 3'-untranslated region (3'-UTR) element which contains a nucleotide sequence derived from 3'-UTR of the ribosomal protein gene.

EFFECT: artificial nucleic acid molecules are disclosed; invention can be used in gene therapy and/or genetic vaccination.

24 cl, 9 dwg, 5 tbl, 1 ex