FIELD: biotechnology.
SUBSTANCE: invention relates to a protein scaffold molecule based on fibronectin type III (FN3) domains for binding to a cellular target. Resulting protein scaffold molecule comprises a polypeptide consensus sequence of a plurality of FN3 domains with an amino acid sequence, selected from a group consisting of sequences SEQ ID NO: 142–151, and can be used to create binding partners for use in diagnostic or therapeutic compositions.
EFFECT: compositions based on stabilized fibronectin domains, methods and applications thereof are disclosed.
10 cl, 8 dwg, 5 tbl, 4 ex
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