FIELD: biotechnology.
SUBSTANCE: what is presented is a Fab fragment of an anti-human MUC1 antibody. Also disclosed are conjugates containing said Fab-fragment for binding to human MUC1 expressed in cancer. Conjugates are used to diagnose and treat malignant growths, such as breast cancer or bladder cancer. Invention also relates to polynucleotides coding a Fab fragment according to the invention, expression vectors and host cells for expressing the Fab fragment, as well as methods for producing Fab fragments and conjugates.
EFFECT: invention provides high activity of binding the Fab-fragment of the antibody with the tumor-specific human MUC1, which is not attenuated during fluorescent labeling of the Fab-fragment and labeling with a chelating agent.
55 cl, 9 dwg, 15 ex
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