FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, specifically to synthesis of 5-hydroxy-1,3,6-trimethyluracil — an immunostimulant with a wide range of pharmacological activity. Method is carried out by oxidation of 6-methyluracil with ammonium persulfate in an alkaline medium at 40–70 °C, followed by cooling the reaction mixture to room temperature, treating formed 6-methyluracil-5-ammonium sulfate with dimethyl sulfate in an alkaline medium at 85–95 °C. Synthesis is carried out in one reactor without extraction of intermediate 6-methyluracil-5-ammonium sulfate. In oxidation of 6-methyluracil, hydrogen peroxide is additionally used as a second oxidant. Intermediate 6-methyluracil-5-ammonium sulfate is treated with dimethyl sulfate at pH 9–10.
EFFECT: high output of the end product.
3 cl, 1 ex
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