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2 126 391

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IPC

(21) (22)

Application

98110871/04, 1998-06-16

(22)

Actual filing date

1998-06-16

(45)

Published

1999-02-20

(72)

Inventor

Krivonogov V.P.Lazareva D.N.Alekhin E.A.Plechev V.V.Tolstikov G.A.Junusov M.S.Timerbulatov V.M.Abdrakhmanov I.B.Zarudij F.S.Lishtakov A.I.Istomin N.N.Galjautdinov A.A.Konovalov Ju.A.Kornilaev P.G.

(73)

Holder

Krivonogov Viktor PetrovichPlechev Vladimir Vjacheslavovich

5-HYDROXY-6-METHYLURACIL SYNTHESIS METHOD Russian patent published in 1999 - IPC

Abstract RU 2126391 C1

FIELD: industrial organic synthesis. SUBSTANCE: 5-hydroxy-6-methyluracil manifests immunotrope activity and is allowed to be applied in medicine and produced on a commercial scale. It can be, in particular, used in treatment of various-genesis immuno-deficiency conditions. Synthesis: reaction mixture obtained on alkali hydrolysis of β-uraminocroton ester is oxidized with ammonium persulfate in alkali medium at 85-95 C. Intermediate product - 6-methyluracil-5-ammonium sulfate (isolated by crystallization or not isolated) is hydrolyzed with sulfuric acid. EFFECT: increased yield and purity of product. 5 ex

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RU 2 126 391 C1

Authors

Krivonogov V.P.

Lazareva D.N.

Alekhin E.A.

Plechev V.V.

Tolstikov G.A.

Junusov M.S.

Timerbulatov V.M.

Abdrakhmanov I.B.

Zarudij F.S.

Lishtakov A.I.

Istomin N.N.

Galjautdinov A.A.

Konovalov Ju.A.

Kornilaev P.G.

Dates

1999-02-20—Published

1998-06-16—Filed