HETEROCYCLIC COMPOUND Russian patent published in 2022 - IPC C07D487/04 A61K31/519 A61P9/04 A61P9/12 A61P11/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (I), where ring A is a benzene ring; R¹ is a hydrogen atom; each of R² and R 3 independently represents a C_1-6 alkyl group; R⁴ is a phenyl group optionally substituted with one or two substituents selected from a group, consisting of a halogen atom, a C_1-6 alkoxy group and C_1-6 alkyl group, optionally substituted with one to three halogen atoms, 5- or 6-member monocyclic aromatic heterocyclic group, containing 1 heteroatom, selected from a nitrogen atom or a sulfur atom, or a C_1-6 alkyl group substituted with one to three halogen atoms, each of R⁵ and R⁶ independently represents a hydrogen atom or a halogen atom, or its pharmaceutically acceptable salt. Invention also relates to a medicinal agent, comprising a compound or a pharmaceutically acceptable salt thereof of formula (I) and a pharmaceutically acceptable carrier, where the drug is an agent for treating heart failure or pulmonary hypertension by calcium-sensitive receptor antagonization.

EFFECT: compounds having calcium-sensitive receptor antagonist activity and used as an agent for preventing or treating heart failure, pulmonary hypertension.

11 cl, 2 dwg, 12 tbl, 59 ex