FIELD: chemistry.
SUBSTANCE: invention relates to tetrahydropyrazolopyrimidine compounds of the general formula (I) in which the radicals and symbols have the definitions indicated in the claims, as well as their variants. These compounds act as antagonists or inhibitors of Toll-like receptors 7 and/or 8. 
(I).
EFFECT: invention also relates to pharmaceutical compositions effective for treating systemic lupus erythematosus (SLE) and lupus nephritis.
47 cl, 81 dwg, 6 tbl
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