FIELD: medicine.
SUBSTANCE: invention relates to experimental medicine, namely to toxicology and ecology, and can be used to simulate toxic cardiopathy. A method for simulating toxic cardiopathy in rats in an experiment consists in the fact that a solution of potassium bichromate in dose of 0.5 mg/kg of body weight in terms of metal is introduced into animals daily for 60 days through a probe into the stomach. At that, per unit of solution equal to 0.3 ml there is 0.05 mg of chromium.
EFFECT: invention provides developing toxic chronic cardiopathy in an animal due to the optimal dose and duration of the metal exposure, which can be used when searching for agents for preventing and treating cardiac pathology.
1 cl, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR SIMULATING CHRONIC TOXIC NEPHROPATHY IN RATS IN EXPERIMENT | 2020 |
|
RU2743843C1 |
| METHOD FOR PREVENTION OF TOXIC COAGULOPATHY IN RATS | 2022 |
|
RU2794030C1 |
| METHOD FOR SIMULATING CHROMIUM-INDUCED COAGULOPATHY IN EXPERIMENTAL RATS | 2020 |
|
RU2743812C1 |
| METHOD FOR PREVENTION OF NEPHROTOXIC ACTION OF CHROMIUM IN RATS IN EXPERIMENT | 2022 |
|
RU2793548C1 |
| METHOD FOR MODELING CHRONIC TOXIC COAGULOPATHY IN RATS IN EXPERIMENT | 2022 |
|
RU2785847C1 |
| METHOD FOR THE PREVENTION OF ALCOHOL-INDUCED NEPHROPATHY ON THE BACKGROUND OF LEAD INTOXICATION IN RATS IN THE EXPERIMENT | 2022 |
|
RU2786469C1 |
| METHOD OF MODELING CHRONIC TOXIC COAGULOPATHY IN RATS | 2023 |
|
RU2800860C1 |
| METHOD FOR PREVENTION OF CHRONIC SUBLEME COAGULOPATHY IN RATS IN EXPERIMENT | 2022 |
|
RU2788609C1 |
| METHOD OF MODELING OF CHRONIC COAGULOPATHY IN EXPERIMENTAL ANIMALS | 2020 |
|
RU2746831C1 |
| METHOD FOR PREVENTION OF NEPHROTOXIC ACTION OF ANTIMONY IN RATS IN EXPERIMENT | 2023 |
|
RU2815874C1 |
