FIELD: medicine.
SUBSTANCE: invention relates to medicine, experimental biology, toxicology and can be used to prevent lesions caused by prolonged alcohol intoxication against the background of lead intoxication in experimental animals. The method includes administering to rats a solution of isovaleric acid amide at a dose of 500 mg/kg together with 40% ethanol at a dose of 3.0 g/kg every day for 30 days and lead acetate at a dose of 25 mg/kg against the background of prophylactic administration of melatonin in dose of 10 mg/kg.
EFFECT: invention provides reduction of toxic effect caused by chronic alcohol and lead intoxication due to stabilization of lipid peroxidation processes and membrane-protective action.
1 cl, 4 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR MODELING ALCOHOL-INDUCED NEPHROPATHY AGAINST THE BACKGROUND OF AUTOIMMUNE NEPHRITIS IN RATS IN AN EXPERIMENT | 2021 |
|
RU2771258C1 |
| METHOD FOR PREVENTION OF NEPHROTOXIC EFFECT OF MOLYBDENUM | 2020 |
|
RU2786641C2 |
| METHOD FOR PREVENTION OF NEPHROTOXIC ACTION OF ANTIMONY IN RATS IN EXPERIMENT | 2023 |
|
RU2815874C1 |
| METHOD FOR PREVENTION OF NEPHROTOXIC ACTION OF CHROMIUM IN RATS IN EXPERIMENT | 2022 |
|
RU2793548C1 |
| METHOD FOR SIMULATING CHRONIC ALCOHOL INTOXICATION IN EXPERIMENTAL RATS | 2020 |
|
RU2740569C1 |
| METHOD FOR MODELING OF CHRONIC TOXIC NEPHROPATHY IN EXPERIMENTAL ANIMALS | 2022 |
|
RU2793544C1 |
| METHOD FOR SIMULATING CHRONIC TOXIC NEPHROPATHY IN RATS IN EXPERIMENT | 2020 |
|
RU2743843C1 |
| METHOD FOR RELIEVING LEAD ACETATE NEPHROTOXICITY | 2010 |
|
RU2458410C1 |
| METHOD FOR RELIEVING LEAD ACETATE NEPHROTOXICITY | 2010 |
|
RU2461072C2 |
| METHOD FOR PREVENTION OF CHRONIC TOXIC COAGULOPATHY IN EXPERIMENTAL ANIMALS | 2018 |
|
RU2683723C1 |
