FIELD: biotechnology.
SUBSTANCE: described is a modified influenza virus, as well as a virus-like particle, wherein said virus or particle comprises an influenza HA protein, where its maturation cleavage site (MCS) is modified so that it is not cleaved by any animal proteases, but it can be cleaved by a protease which is not present in known natural hosts of the influenza virus, where during cleavage glycine is preserved at the N-terminus of HA2. Also described is a nucleic acid coding an effective portion of the HA protein of said influenza virus. Also disclosed is a corresponding expression vector and a host cell. Disclosed is a method for preparing a virus or virus-like particle (VLP) containing a modified HA protein. Immunogenic compositions containing the described modified influenza virus or expression vector are described.
EFFECT: invention extends the range of agents for controlling influenza.
17 cl, 8 dwg, 2 tbl, 7 ex
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