FIELD: pharmaceuticals.
SUBSTANCE: invention relates to specific derivatives of dihydropyrimidin-2-one specified in Claim 1 of the claims, their pharmaceutically acceptable salts, a pharmaceutical composition based on them, a drug, a method for inhibiting RORγ, a method for treating diseases and application.
EFFECT: dihydropyrimidine-2-one derivatives that have an inhibitory effect on the retinoid-related orphan receptors gamma (RORγ), used in treatment of diseases mediated by RORγ inhibition, selected from a group consisting of autoimmune, allergic, metabolic diseases, dry eyes and fibrosis.
34 cl, 6 tbl, 360 ex
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