SEZ6 ANTIBODY-DRUG CONJUGATE AND METHODS FOR APPLICATION Russian patent published in 2022 - IPC C07K16/28 A61K47/68 

Abstract RU 2770474 C1

FIELD: biotechnology.

SUBSTANCE: described is an antibody-drug conjugate (ADC) for delivering a drug to human SEZ6-expressing cells, wherein the conjugate has the structure:

,

wherein the antibody (Ab) contains an anti-SEZ6 antibody with the heavy chain sequence SEQ ID NO: 3 and the light chain sequence SEQ ID NO: 4, and wherein n equals 2.

EFFECT: invention expands the range of means for delivering a drug to human SEZ6-expressing cells.

1 cl, 9 dwg, 6 tbl, 10 ex

Similar patents RU2770474C1

Title Year Author Number
SUBUNIT VACCINE FOR TREATING OR PREVENTING RESPIRATORY TRACT INFECTION 2020
  • Perudzhi, Faben
  • Shvamborn, Klaus
  • Shyuler, Volfgang
  • Lundberg, Urban
  • Majnke, Andreas
RU2811991C2
ANTIBODIES TO IL-6 AND THEIR FUSIONS AND CONJUGATES 2019
  • Dzhejkobson, Rejchel D.
  • Korrea, Fernando
  • Lyan, Khun
  • Perlrot, D. Viktor
RU2810777C2
CONJUGATES OF ANTIBODIES TO STAPHYLOCOCCUS AUREUS WITH RIFAMYCIN AND USE THEREOF 2015
  • Brown Eric
  • Hazenbos Wouter
  • Hotzel Isidro
  • Kajihara Kimberly
  • Lehar Sophie M.
  • Mariathasan Sanjeev
  • Pillow Thomas
  • Staben Leanna
  • Verma Vishal
  • Wei Binqing
  • Xu Min
RU2731055C2
ANTIGENIC POLYPEPTIDES BASED ON THE RESPIRATORY SYNCYTIAL VIRUS SEQUENCE 2019
  • Nejbel, Gari Dzh.
  • Vej, Chikh-Dzhen
  • Svenson, Kurt
  • Dkhal, Pradip
  • Dkharanipragada, Ram
  • Besev, Magnus
RU2807992C2
SCREENING OF ATTACHMENT SITES WITH FIXED POINT IN CYSTEINE-MODIFIED ANTIBODY-TOXIN (TDC) CONJUGATE 2018
  • Zhu, Yi
  • Wang, Yiqian
  • Zhuo, Shi
  • Li, Jie
  • Yu, Yongguo
  • Wan, Weili
RU2816510C2
RSV F MUTANT PROTEIN AND ITS APPLICATION 2020
  • Hogiri, Tomoharu
  • Kishida, Hiroyuki
  • Takedomi, Kei
  • Branduardi, Davide
  • Oloo, Eliud
  • Feyfant, Eric
  • Ichihara, Osamu
RU2807742C1
MOLECULES BINDING MESOTHELIN AND CD137 2019
  • Munos-Olajya, Khose
  • Tyuna, Mikhriban
  • Fertin, Remi
  • Rider, Kler
  • Vollerton, Frantsiska
  • Bryuvis, Nil
RU2815066C2
POLYPEPTIDE LINKER FOR PRODUCTION OF MULTI-SPECIFIC ANTIBODIES 2018
  • Zhukovsky, Eugene
  • Leger, Olivier
RU2776302C2
MODIFIED ANTIBODY CONSTANT REGION 2021
  • Igava Tomoyuki
  • Siraiva Khirotke
RU2797273C2
HPV-SPECIFIC BINDING MOLECULES 2018
  • Brandt, Cameron
  • Belmont, Brian
  • Borges, Christopher
  • Burleigh, Stephen Michael
  • Croft, Alexandra
  • Goldfless, Stephen Jacob
  • Huss, David Jeffrey
  • Jiang, Yue
  • Johnstone, Timothy G.
  • Koppstein, David
  • Nguyen, Hieu
  • Nye, Christopher Heath
  • Peper, Haley
  • Sather, Blythe D.
  • Timberlake, Sonia
  • Toy, Dean Y.
  • Vong, Queenie
  • Welstead, Gordon Grant
  • Sissons, James
RU2804664C2

RU 2 770 474 C1

Authors

Liu, David

Gavrilyuk, Julia

Schammel, Alexander

Dates

2022-04-18Published

2019-05-30Filed