MODIFIED CONSTANT REGION OF ANTIBODY Russian patent published in 2025 - IPC C07K16/00 

Abstract RU 2837820 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, in particular to the constant region of IgG2, in which His at position 147, Arg at position 234 and Gln at position 298 in the amino acid sequence SEQ ID NO: 2 are replaced by Gln, Gln and Glu, respectively, to the constant region of IgG2, in which Cys at position 14, Arg at position 16, Cys at position 102, Glu at position 20, Ser at position 21, His at position 147, Arg at position 234 and Gln at position 298 in the amino acid sequence SEQ ID NO: 2 are replaced by Ser, Lys, Ser, Gly, Gly, Gln, Gln and Glu, respectively, and also to the constant region of IgG2, in which Cys at position 14, Arg at position 16, Cys at position 102, Glu at position 20, Ser at position 21, His at position 147, Arg at position 234, Gln at position 298 and Asn at position 313 in the amino acid sequence SEQ ID NO: 2 are replaced by Ser, Lys, Ser, Gly, Gly, Gln, Gln, Glu and Ala, respectively.

EFFECT: invention is effective for improving the pharmacokinetics of the antibody.

3 cl, 24 dwg, 5 tbl, 12 ex

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RU 2 837 820 C2

Authors

Igava Tomoyuki

Siraiva Khirotake

Dates

2025-04-07Published

2023-05-26Filed