FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to options of antibodies with a reduced level of binding with technological impurities. Obtained options of IgG4 antibodies, modified in a constant region of a heavy chain, include substitution of R222 with T or K and/or substitution of YGPP, as defined in SEQ ID NO: 23, by residues 229, 230, 237 and 238 by Kabat numeration, with CCVE, as defined in SEQ ID NO: 25.
EFFECT: obtained antibodies have a reduced level of binding with PLBL2 and can be used for the therapeutic, proactive or preventive treatment.
21 cl, 10 dwg, 11 tbl, 13 ex
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